Third-Party Tested ≥98% HPLC Purity — USA Shipped

5-Amino-1MQ 5mg - Research Peptide
Weight Management 5mg

5-Amino-1MQ

$37.50 In Stock

NNMT modulator for metabolic and weight management research.

$37.50
1
≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

NNMT modulator for metabolic and weight management research.

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and depletes the cellular pool of S-adenosyl methionine (SAM), a critical methyl donor. By inhibiting NNMT, 5-Amino-1MQ is proposed to increase intracellular NAD+ levels and SAM availability, thereby enhancing cellular energy metabolism and epigenetic regulation. Research published by Neelakantan et al. (Biochemical Pharmacology, 2018) demonstrated that NNMT inhibition in diet-induced obese mice reduced body weight and white adipose tissue mass while increasing energy expenditure, without changes in food intake. The same research group at the University of Texas showed that NNMT expression is upregulated in visceral adipose tissue of obese subjects, suggesting the enzyme plays a direct role in metabolic dysfunction. Unlike GLP-1 receptor agonists that suppress appetite centrally, 5-Amino-1MQ operates at the cellular metabolic level by modulating the NAD+ salvage pathway and methylation balance, offering a mechanistically distinct approach. Compared to NMN or NR supplementation (NAD+ precursors), 5-Amino-1MQ addresses NAD+ depletion at the enzymatic level rather than through precursor loading. Studies also suggest NNMT inhibition may improve insulin sensitivity through enhanced SIRT1 activity. Store lyophilized powder at -20C protected from moisture; reconstitute in sterile water as needed. This compound is investigated by metabolic biochemistry laboratories, NAD+ biology researchers, and academic institutions studying the intersection of epigenetics and obesity.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 5mg of research-grade material.

Read the full 5-Amino-1MQ research guide

Research Applications

  • Obesity and metabolic syndrome studies
  • Insulin resistance and type 2 diabetes research
  • NAD+ optimization for anti-aging
  • Energy and endurance performance

Specifications

Size
5mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder
Molecular Formula
C10H11N2O
Molecular Weight
175.21 g/mol

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is 5-Amino-1MQ and how does it work?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates cellular energy metabolism and NAD+ levels. By inhibiting NNMT, 5-Amino-1MQ has been observed in preclinical models to increase intracellular NAD+ concentrations and activate the sirtuin (SIRT1) pathway, influencing fat cell metabolism, energy expenditure, and metabolic homeostasis.
What research has been done on 5-Amino-1MQ?
Research published in Biochemical Pharmacology demonstrated that 5-Amino-1MQ inhibited NNMT activity in adipocyte models, leading to reduced fat cell size and lipid accumulation. Studies at the University of Texas Health Science Center showed that NNMT inhibition by this compound class increased SAM (S-adenosylmethionine) concentrations and decreased fat mass in diet-induced obesity models without affecting food intake.
How does 5-Amino-1MQ compare to other NNMT inhibitors?
5-Amino-1MQ is among the most potent and selective NNMT inhibitors studied to date. Compared to earlier NNMT inhibitors like JBSNF-000088, 5-Amino-1MQ demonstrates superior cell permeability and selectivity. Unlike broad-spectrum metabolic modulators such as metformin, it targets a single enzyme (NNMT) with high specificity, making it a valuable tool compound for studying the NNMT-NAD+ axis in metabolic research.
What is the recommended reconstitution protocol for 5-Amino-1MQ?
For this 5mg vial, reconstitute with 1mL of bacteriostatic water to yield a concentration of 5.0mg/mL. Inject the water slowly along the inner wall of the vial — do not shake or agitate. Allow the lyophilized powder to dissolve fully (typically 2-5 minutes). Store reconstituted solution at 2-8°C and use within 30 days.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.