Tesamorelin

Description

Synthetic GHRH analogue studied for visceral fat reduction and metabolic health.

Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) consisting of the 44-amino acid human GHRH sequence with a trans-3-hexenoic acid modification at the N-terminus. It acts by binding to GHRH receptors on anterior pituitary somatotroph cells, stimulating pulsatile growth hormone (GH) release while preserving the natural hypothalamic-pituitary feedback axis. Tesamorelin received FDA approval (marketed as Egrifta) for reduction of excess abdominal fat in HIV-infected patients with lipodystrophy, based on pivotal trials demonstrating approximately 15-18% reduction in visceral adipose tissue over 26 weeks (Falutz et al., JAMA 2007). Beyond lipodystrophy research, studies published in Annals of Neurology (Baker et al., 2012) suggest tesamorelin may improve cognitive function in older adults with mild cognitive impairment by modulating IGF-1 levels in the central nervous system. Compared to direct GH administration, tesamorelin preserves physiological GH pulsatility rather than creating supraphysiological sustained GH levels, which research indicates may reduce the risk of insulin resistance associated with exogenous GH. Additional preclinical work has explored its role in peripheral nerve regeneration models. The lyophilized powder should be stored at controlled room temperature (20-25C) or refrigerated; reconstitute with sterile water and use within 24 hours or refrigerate for up to 14 days. This peptide is studied by endocrinology research labs, HIV metabolism centers, and neuroscience institutions investigating GH-IGF-1 axis modulation.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 5mg of research-grade material.

Research Applications

• HIV-associated lipodystrophy and visceral fat reduction
• Peripheral nerve regeneration
• Mild cognitive impairment research
• Cardiovascular health through metabolic markers

Specifications

Size

5mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Molecular Formula

C223H370N72O69S

Molecular Weight

5195.91 g/mol

CAS Number

901758-09-6

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection