AOD-9604 5mg

Description

Synthetic hGH fragment 176-191 analogue for lipid metabolism research.

AOD-9604 is a modified 16-amino acid fragment corresponding to the C-terminal region (residues 176-191) of human growth hormone, with a tyrosine substitution that modulates its lipolytic activity. Its mechanism of action involves stimulating lipolysis and inhibiting lipogenesis in adipose tissue through a pathway distinct from the GH receptor, meaning it does not promote IGF-1 elevation or the diabetogenic effects associated with full-length growth hormone. Research conducted at Monash University by Ng et al. (Obesity Research, 2000) demonstrated that AOD-9604 reduced body fat in obese Zucker rats without affecting glucose tolerance or inducing growth-promoting effects. A subsequent human clinical trial (Stier et al., 2013) examined oral formulations and found the compound was well-tolerated, though metabolic-pathway research results were modest compared to research-grade use in preclinical models. AOD-9604 was granted GRAS (Generally Recognized As Safe) status by the FDA in 2014 for use as a food supplement ingredient, distinguishing it from most peptides in its regulatory profile. Compared to full-length hGH, AOD-9604 offers a more targeted approach to fat metabolism research without the broad anabolic and insulin-resistance concerns. Additional preclinical studies suggest potential applications in cartilage repair and osteoarthritis models. Store the lyophilized powder at -20C; reconstitute with bacteriostatic water and refrigerate at 2-8C, using reconstituted material within 21 days. AOD-9604 is studied by metabolic research laboratories, sports science institutions, and orthopedic research groups investigating cartilage regeneration.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 5mg of research-grade material.

Research Applications

• Lipolysis and fat metabolism studies
• Adipocyte size reduction research
• Glucose and insulin regulation
• Body composition optimization

Specifications

Size

5mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection