Thymosin Alpha-1

Description

Natural immune regulator for T-cell maturation and infection research.

Thymosin Alpha-1 (Ta1) is a 28-amino acid peptide naturally derived from prothymosin alpha in the thymus gland, playing a critical role in immune system maturation and regulation. It functions as a biological response modifier, enhancing T-cell differentiation from bone marrow stem cells, promoting dendritic cell maturation, and augmenting natural killer cell cytotoxicity. Ta1 activates toll-like receptors (TLR2 and TLR9), stimulating both innate and adaptive immune pathways. Thymosin Alpha-1 has been among the most clinically studied peptides in immunology. Research published in the Annals of the New York Academy of Sciences by Garaci et al. demonstrated that Ta1 enhanced immune reconstitution in immunocompromised subjects. A pivotal study by Andreone et al. (2001) in Gut showed that Ta1 produced sustained virological responses in chronic hepatitis B comparable to interferon-alpha, with significantly fewer adverse effects. Studies in Critical Care Medicine indicated that Ta1 administration in sepsis models improved survival rates and reduced inflammatory biomarkers, leading to its adoption in clinical sepsis protocols in several countries. Compared to thymulin and Thymalin, which are also thymus-derived peptides, Thymosin Alpha-1 has the most extensive clinical evidence base. Thymulin primarily affects T-cell differentiation through zinc-dependent mechanisms, while Ta1 has broader immunomodulatory reach including dendritic cell activation. Unlike synthetic immunostimulants such as levamisole, Ta1 modulates rather than simply stimulates immunity, reducing the risk of autoimmune overstimulation. Store lyophilized Thymosin Alpha-1 at -20°C. Reconstitute with bacteriostatic water and refrigerate at 2-8°C, using within 4 weeks. This peptide is studied by immunologists, oncology researchers investigating adjuvant immunotherapy, and infectious disease specialists working on hepatitis and sepsis treatment strategies.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

• Immune system modulation and T-cell maturation
• Sepsis treatment studies
• Hepatitis B and C research
• Cancer immunotherapy studies

Specifications

Size

10mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Molecular Formula

C129H215N33O55

Molecular Weight

3108.315 g/mol

CAS Number

62304-98-7

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection