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Sermorelin Acetate 10mg - Research Peptide
Body Composition 10mg

Sermorelin Acetate

$109.00 In Stock

Synthetic GHRH analogue for natural growth hormone stimulation research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Synthetic GHRH analogue for natural growth hormone stimulation research.

Sermorelin acetate is a synthetic 29-amino acid peptide corresponding to the first 29 residues of the 44-amino acid human growth hormone-releasing hormone (GHRH 1-29). It represents the shortest fully functional fragment of GHRH capable of activating the GHRH receptor on anterior pituitary somatotrophs. Sermorelin was FDA-approved (marketed as Geref) for diagnostic evaluation of pituitary GH secretory capacity and was previously used in pediatric growth hormone deficiency research. Its mechanism involves GHRH-R binding, which activates adenylyl cyclase-cAMP-PKA signaling to stimulate GH gene transcription, synthesis, and pulsatile release. Clinical studies by Vittone et al. (Journal of Clinical Endocrinology and Metabolism, 1997) demonstrated that sermorelin administration in elderly subjects increased GH secretion and improved body composition markers including lean body mass and skin thickness. Importantly, because sermorelin works through the native GHRH receptor, GH release remains subject to somatostatin-mediated negative feedback, preserving physiological regulation unlike direct GH administration. Research has also explored sermorelin in cardiovascular contexts, where GH-IGF-1 axis activation may support cardiac tissue remodeling, and in seizure models where GHRH receptor activation appears to have neuroprotective effects. Compared to CJC-1295 (with or without DAC), sermorelin has a shorter half-life of approximately 10-20 minutes, requiring more frequent administration but producing very precise, physiological GH pulses. Store lyophilized powder at -20C; reconstitute with bacteriostatic water and refrigerate at 2-8C for up to 14 days. Sermorelin is studied by pediatric endocrinology research centers, geriatric medicine departments, and cardiovascular research institutions investigating GH axis modulation.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

  • Cardiovascular tissue regeneration
  • Neurological and seizure research
  • Sleep quality improvement studies
  • Bone mineral density enhancement

Specifications

Size
10mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder
Molecular Formula
C187H291N45O59
Molecular Weight
4113.58 g/mol
CAS Number
910463-68-2

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is Sermorelin Acetate and how does it work?
Sermorelin is a synthetic peptide corresponding to amino acids 1-29 of human growth hormone-releasing hormone (GHRH). This 29-amino acid fragment retains the full biological activity of the 44-amino acid native GHRH. It stimulates pulsatile GH release from the anterior pituitary by binding GHRH receptors, preserving the natural feedback mechanisms that regulate GH secretion — unlike exogenous GH administration, which bypasses pituitary regulation.
What research has been done on Sermorelin?
Sermorelin received FDA approval for diagnostic use (GH deficiency testing) and was previously approved therapeutically for children with growth failure. Published research in the Journal of Clinical Endocrinology & Metabolism demonstrated restoration of youthful GH pulsatility patterns in aging subjects. Studies have also explored its cardioprotective effects, with research showing improved cardiac function and reduced fibrosis in heart failure models.
How does Sermorelin compare to CJC-1295 (without DAC)?
Both are GHRH receptor agonists, but CJC-1295 includes four amino acid substitutions that provide resistance to DPP-IV enzymatic degradation, giving it a longer half-life (approximately 30 minutes vs. Sermorelin's 10-20 minutes). Sermorelin has more extensive clinical data and a history of FDA approval. CJC-1295 may be preferred for research requiring longer-duration GHRH receptor stimulation per administration.
What is the recommended reconstitution protocol for Sermorelin?
For this 10mg vial, reconstitute with 2mL of bacteriostatic water for a 5mg/mL solution. Sermorelin dissolves within 2-4 minutes due to its relatively large molecular weight (4113.58 g/mol). Add water along the vial wall gently. Store reconstituted solution at 2-8°C and use within 30 days. Protect from light.
What purity testing is performed on Sermorelin?
Sermorelin undergoes HPLC purity analysis (minimum 98%), mass spectrometry for molecular weight verification (4113.58 g/mol), and amino acid analysis to confirm the correct 29-amino acid sequence. Acetate counterion content is measured. Additional testing includes endotoxin levels, residual solvents, and water content. A Certificate of Analysis (COA) is provided with each batch.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.