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CJC-1295 (without DAC) 10mg - Research Peptide
Body Composition 10mg

CJC-1295 (without DAC)

$79.00 In Stock

Modified GHRH analogue for growth hormone release research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Modified GHRH analogue for growth hormone release research.

CJC-1295 without DAC (also known as Modified GRF 1-29 or Mod GRF) is a synthetic 29-amino acid peptide analogue of growth hormone-releasing hormone (GHRH) with four amino acid substitutions (positions 2, 8, 15, and 27) that confer resistance to DPP-IV enzymatic degradation. Its mechanism of action involves binding to GHRH receptors (GHRH-R) on anterior pituitary somatotroph cells, stimulating cAMP-mediated signaling that triggers growth hormone synthesis and secretion. The amino acid modifications extend the peptide's biological half-life from under 10 minutes (native GHRH) to approximately 30 minutes, enabling meaningful GH pulse amplification while still preserving physiological pulsatile release patterns. Research on this modified GHRH analogue demonstrates it produces GH elevations within 15-30 minutes of administration, with return to baseline within 2-3 hours, mimicking natural GH pulse kinetics. Studies suggest CJC-1295 without DAC may support skin thickness and collagen production through GH-mediated IGF-1 elevation (Ionescu and Bhatt, Growth Hormone and IGF Research). Compared to the DAC-conjugated version (CJC-1295 with DAC), the non-DAC form produces shorter, more discrete GH pulses rather than sustained 7-10 day GH elevation, which some research protocols prefer for mimicking physiological patterns. It is frequently paired with ghrelin mimetics like ipamorelin for synergistic effect. Store lyophilized powder at -20C; reconstitute with bacteriostatic water and refrigerate at 2-8C for up to 21 days. This peptide is studied by endocrinology research departments, anti-aging medicine laboratories, and body composition research centers investigating GHRH axis modulation.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

  • Pituitary GH release stimulation
  • Skin thickness and collagen activity
  • Muscle hypertrophy studies
  • Cardiac tissue repair research

Specifications

Size
10mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder
Molecular Formula
C152H252N44O42
Molecular Weight
3367.9 g/mol

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is CJC-1295 (without DAC) and how does it work?
CJC-1295 without DAC (also called Mod GRF 1-29) is a modified growth hormone-releasing hormone analogue consisting of the first 29 amino acids of GHRH with four amino acid substitutions (positions 2, 8, 15, and 27). These modifications protect it from enzymatic degradation by DPP-IV, extending its half-life to approximately 30 minutes. It stimulates pulsatile GH release by binding to GHRH receptors on pituitary somatotroph cells.
What research has been done on CJC-1295 (without DAC)?
Published research in the Journal of Clinical Endocrinology & Metabolism demonstrated that CJC-1295 produced dose-dependent increases in GH and IGF-1 levels. Studies have shown it amplifies natural GH pulsatility rather than creating a continuous GH elevation, which more closely mimics physiological GH secretion patterns. Additional research has explored its effects on body composition, skin collagen density, and cardiac tissue repair in animal models.
How does CJC-1295 without DAC compare to CJC-1295 with DAC?
The key difference is the Drug Affinity Complex (DAC). Without DAC, CJC-1295 has a half-life of approximately 30 minutes and produces acute GH pulses that mimic natural secretion. With DAC, albumin binding extends the half-life to 6-8 days, creating sustained GH elevation. Researchers studying pulsatile GH patterns prefer the non-DAC version, while sustained GH exposure models use the DAC variant.
What is the recommended reconstitution protocol for CJC-1295 (without DAC)?
For this 10mg vial, reconstitute with 2mL of bacteriostatic water for a 5mg/mL solution. CJC-1295 dissolves within 2-4 minutes. Add water along the vial wall to preserve peptide integrity. Avoid shaking, as this large peptide (3367.9 g/mol) can aggregate. Store reconstituted solution at 2-8°C and use within 30 days.
What purity testing is performed on CJC-1295 (without DAC)?
CJC-1295 (without DAC) undergoes HPLC purity analysis (minimum 98%), mass spectrometry for molecular weight verification (3367.9 g/mol), and amino acid analysis to confirm the four key substitutions that distinguish it from native GHRH. Endotoxin testing, residual solvent analysis, and peptide content determination are also performed. A COA is provided.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.