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Kisspeptin-10 10mg - Research Peptide
Body Composition 10mg

Kisspeptin-10

$109.00 In Stock

Neuropeptide for reproductive hormone and metabolic research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Neuropeptide for reproductive hormone and metabolic research.

Kisspeptin-10 is the minimal bioactive C-terminal decapeptide fragment of the full-length kisspeptin-54 (metastin), encoded by the KISS1 gene. It acts as an endogenous ligand for the GPR54 receptor (KISS1R), a G-protein coupled receptor expressed predominantly on hypothalamic GnRH neurons. Kisspeptin-10 binding to KISS1R potently stimulates gonadotropin-releasing hormone (GnRH) secretion, which in turn drives luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from the anterior pituitary, making it a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Landmark research by Dhillo et al. (2005) published in The Journal of Clinical Endocrinology & Metabolism demonstrated that intravenous Kisspeptin-10 administration in healthy men produced potent, dose-dependent increases in plasma LH, FSH, and testosterone levels. Studies by Jayasena et al. (2011) in the same journal showed that kisspeptin infusion restored LH pulsatility in women with hypothalamic amenorrhea. Research published in Human Reproduction by Abbara et al. demonstrated that kisspeptin could safely trigger oocyte maturation in IVF protocols with reduced risk of ovarian hyperstimulation syndrome compared to hCG triggers. Compared to GnRH analogues (leuprolide, gonadorelin), Kisspeptin-10 acts upstream at the hypothalamic level, providing a more physiological stimulus pattern. Unlike continuous GnRH agonist exposure, which causes receptor desensitization and eventual HPG axis suppression, kisspeptin appears to maintain responsiveness, making it valuable for studying natural reproductive physiology. Store lyophilized Kisspeptin-10 at -20°C. Reconstitute with bacteriostatic water and store at 2-8°C, using within 3 weeks. This peptide is actively researched by reproductive endocrinologists, fertility scientists, neuroendocrinologists, and metabolic researchers studying kisspeptin's emerging roles in glucose homeostasis and body composition.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

  • Reproductive hormone regulation
  • GnRH pathway modulation
  • Body composition studies
  • Metabolic signaling research

Specifications

Size
10mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is Kisspeptin-10 and how does it work?
Kisspeptin-10 is a 10-amino acid C-terminal fragment of the full-length kisspeptin protein (encoded by the KISS1 gene). It binds to the GPR54/KISS1R receptor on GnRH (gonadotropin-releasing hormone) neurons in the hypothalamus, triggering GnRH release. This initiates the hypothalamic-pituitary-gonadal (HPG) axis cascade, leading to LH and FSH secretion. Kisspeptin-10 retains the full receptor-binding activity of the larger kisspeptin forms.
What research has been done on Kisspeptin-10?
Landmark research published in the New England Journal of Medicine demonstrated that kisspeptin administration potently stimulated LH and FSH release in human subjects. Studies at Imperial College London (Journal of Clinical Investigation) showed kisspeptin's role in regulating reproductive hormone pulsatility. Additional research has explored its diagnostic potential for hypothalamic amenorrhea, its role in puberty onset, and its effects on metabolic signaling through HPG axis interactions.
How does Kisspeptin-10 compare to GnRH analogues?
Kisspeptin-10 acts upstream of GnRH — it stimulates endogenous GnRH release rather than directly activating GnRH receptors. This preserves the natural pulsatile pattern of GnRH secretion, whereas exogenous GnRH analogues (leuprolide, goserelin) can cause receptor desensitization and paradoxical hormone suppression with continuous use. Kisspeptin research provides a more physiological tool for studying HPG axis regulation.
What is the recommended reconstitution protocol for Kisspeptin-10?
For this 10mg vial, reconstitute with 2mL of bacteriostatic water for a 5mg/mL solution. Kisspeptin-10 dissolves within 2-3 minutes. Add water along the vial wall without agitation. Store reconstituted solution at 2-8°C and use within 30 days.
What purity testing is performed on Kisspeptin-10?
Kisspeptin-10 undergoes HPLC purity analysis (minimum 98%), mass spectrometry for molecular weight verification, and amino acid analysis to confirm the correct 10-residue C-terminal sequence. Special attention is paid to C-terminal amidation, which is required for receptor binding. Endotoxin testing and residual solvent analysis are performed. A Certificate of Analysis (COA) is included.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.