Cognitive Research Guide

Selank: Dosage, Benefits & Research Guide

Also known as: Tuftsin analog TP-7

Key Facts

Selank is a cognitive research peptide (C33H57N11O9, MW 751.87 g/mol). Synthetic tuftsin analogue for anxiety and cognitive function research. It is supplied as a lyophilized powder for laboratory and in-vitro research use only — not for human consumption.

Classification	Synthetic tuftsin-analog heptapeptide (anxiolytic research peptide)
Molecular Formula	C33H57N11O9
Molecular Weight	751.87 g/mol
CAS Number	129954-34-3
Research Half-Life	Very short in plasma
Form	Lyophilized powder
Research Category	Cognitive

What is Selank?

Selank is a synthetic heptapeptide analogue of the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), extended with a Pro-Gly-Pro sequence for enhanced metabolic stability. Selank exerts its effects primarily through modulation of the GABAergic system, influencing GABA-A receptor subunit expression and monoamine neurotransmitter metabolism, particularly serotonin and norepinephrine. It also demonstrates immunomodulatory activity by regulating cytokine balance and enhancing phagocytic activity. Research conducted at the Institute of Molecular Genetics in Moscow revealed that Selank significantly altered the expression of 36 genes related to GABAergic neurotransmission in hippocampal tissue (Zozulya et al., 2001). Studies in Bulletin of Experimental Biology and Medicine demonstrated anxiolytic effects comparable to benzodiazepines but without sedation, motor impairment, or dependence risk. Further work by Kozlovskii and Danchev showed that Selank enhanced memory trace stability in rodent avoidance tasks, suggesting dual anxiolytic-nootropic activity. Compared to Semax, Selank produces a calming, anxiolytic profile rather than a stimulatory cognitive boost. Where Semax primarily modulates BDNF and melanocortin pathways, Selank operates through GABA modulation and immune regulation. Diazepam and other classical anxiolytics share Selank's target system but carry tolerance and withdrawal risks that research suggests Selank does not. Store lyophilized Selank at -20°C in a desiccated environment. After reconstitution with bacteriostatic water, refrigerate at 2-8°C and use within 3-4 weeks. Selank is primarily studied by neuropharmacologists, behavioral researchers investigating anxiety models, and immunologists examining peptide-based immune modulation.

Selank Research Applications

In published and preclinical research, Selank has been studied across the following areas:

Anxiety management and GABA modulation
Immunomodulation studies
Cognitive enhancement and memory
Pain modulation via opioid receptors

Selank in Research: Reconstitution & Study Concentrations

Selank is a synthetic heptapeptide based on the immunopeptide tuftsin, studied for anxiolytic, immunomodulatory and GABAergic/BDNF-related endpoints. Research concentrations are model-specific; reconstitute with bacteriostatic or sterile water for laboratory use only.

Worked example: a 11mg vial reconstituted with 2 mL of bacteriostatic water yields 5.50 mg/mL.

Open the reconstitution calculator

How Selank Compares

Researchers frequently evaluate Selank alongside related compounds:

Selank vs Semax — the companion nootropic research peptide

Selank — Frequently Asked Questions

What is Selank and how does it work?

Selank is a synthetic heptapeptide based on the naturally occurring immunopeptide tuftsin (Thr-Lys-Pro-Arg) with an added Gly-Pro sequence for stability. It has been observed to modulate GABAergic neurotransmission, stabilize enkephalins (endogenous opioid peptides), and influence the expression of interleukin-6 and other immune markers. These combined anxiolytic, nootropic, and immunomodulatory properties make it a multi-target research compound.

What research has been done on Selank?

Selank was developed at the Institute of Molecular Genetics (Russian Academy of Sciences) and approved in Russia as an anxiolytic. Published research in Bulletin of Experimental Biology and Medicine demonstrated anxiolytic effects comparable to benzodiazepines but without sedation or dependence. Studies showed Selank modulates the expression of 36 genes involved in GABAergic neurotransmission. Additional research has explored its immunostimulatory effects through tuftsin pathway activation.

How does Selank compare to benzodiazepines or Semax?

Unlike benzodiazepines, Selank modulates GABA signaling without direct receptor binding, avoiding sedation, tolerance, and dependence observed with traditional anxiolytics. Compared to Semax (which upregulates BDNF for cognitive enhancement), Selank's primary mechanism involves enkephalin stabilization and immune modulation. Researchers studying anxiety models typically choose Selank, while cognitive enhancement models favor Semax.

What is the recommended reconstitution protocol for Selank?

For this 11mg vial, reconstitute with 2mL of bacteriostatic water to yield a concentration of 5.5mg/mL. Inject the water slowly along the inner wall of the vial — do not shake or agitate. Allow the lyophilized powder to dissolve fully (typically 2-5 minutes). Store reconstituted solution at 2-8°C and use within 30 days.

Is Selank legal to buy for research?

Selank is sold in the United States as a research chemical for laboratory and in-vitro use only. It is not approved by the FDA for human use and is not sold for human consumption. Researchers are responsible for compliance with all applicable federal, state, and institutional regulations.

How is Selank reconstituted for research use?

Selank ships as a lyophilized (freeze-dried) powder and is reconstituted with bacteriostatic or sterile water before use in research. The volume of solvent added determines the working concentration — use the Elyte reconstitution calculator to derive the exact concentration for a given vial size and solvent volume.

Does Selank come with a Certificate of Analysis?

Yes. Every batch of Selank from Elyte Peptides ships with a third-party Certificate of Analysis (COA) documenting identity and HPLC purity (≥98%), so research results can be traced to a verified lot.

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