Pinealon: Dosage, Benefits & Research Guide
What is Pinealon?
Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg (EDR) that belongs to the Khavinson peptide bioregulator family. It was designed to target pineal gland function, and research suggests it penetrates cell membranes and interacts directly with DNA, modulating gene expression related to neuroprotection and circadian regulation. Its mechanism of action involves upregulation of serotonin synthesis enzymes and modulation of melatonin production pathways in pinealocytes. Research by Khavinson et al. published in Bulletin of Experimental Biology and Medicine demonstrated that Pinealon exhibited neuroprotective effects in cortical neuron cultures exposed to hypoxic and oxidative stress conditions, reducing cell death by up to 40% compared to controls. Additional studies showed that EDR peptide administration in aged animal models helped restore circadian melatonin rhythms that had deteriorated with age. Work published in Advances in Gerontology indicated that Pinealon improved memory consolidation and learning capacity in senescence-accelerated mice. Compared to Epithalon (AEDG), another Khavinson bioregulator peptide targeting the pineal gland, Pinealon operates through distinct mechanisms. While Epithalon primarily activates telomerase and elongates telomeres, Pinealon focuses on direct neuroprotective gene regulation and serotonin pathway support. The two are sometimes studied in conjunction for comprehensive pineal gland and aging research. Lyophilized Pinealon should be stored at -20°C. Reconstitute with bacteriostatic water immediately before use and store at 2-8°C for up to 3 weeks. Researchers in gerontology, chronobiology, and neuroprotection are the primary investigators of this peptide, particularly those studying age-related cognitive decline and circadian disruption.
Pinealon Research Applications
In published and preclinical research, Pinealon has been studied across the following areas:
- Neuroprotection against hypoxia
- Circadian rhythm regulation
- Memory consolidation and learning
- Serotonin pathway research
Pinealon in Research: Reconstitution & Study Concentrations
Pinealon is supplied as a lyophilized powder. For laboratory research it is reconstituted with bacteriostatic or sterile water; the solvent volume sets the working concentration. Published studies select concentrations specific to the assay or model system — there is no human dose, as Pinealon is not approved for human use. Researchers should reference the primary literature for the model in question and document the exact lot COA.
Worked example: a 20mg vial reconstituted with 2 mL of bacteriostatic water yields 10.00 mg/mL.
Open the reconstitution calculator