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Body Composition Research Guide

CJC-1295 (without DAC): Dosage, Benefits & Research Guide

Also known as: CJC-1295 no DAC, Modified GRF 1-29, Mod-GRF 1-29

Key Facts

CJC-1295 (without DAC) is a body composition research peptide (C152H252N44O42, MW 3367.9 g/mol). Modified GHRH analogue for growth hormone release research. It is supplied as a lyophilized powder for laboratory and in-vitro research use only — not for human consumption.

Classification Modified growth-hormone-releasing hormone analog (no Drug Affinity Complex)
Molecular Formula C152H252N44O42
Molecular Weight 3367.9 g/mol
Research Half-Life ~30 minutes — short, producing pulsatile GH-release research profiles
Form Lyophilized powder
Research Category Body Composition

What is CJC-1295 (without DAC)?

CJC-1295 without DAC (also known as Modified GRF 1-29 or Mod GRF) is a synthetic 29-amino acid peptide analogue of growth hormone-releasing hormone (GHRH) with four amino acid substitutions (positions 2, 8, 15, and 27) that confer resistance to DPP-IV enzymatic degradation. Its mechanism of action involves binding to GHRH receptors (GHRH-R) on anterior pituitary somatotroph cells, stimulating cAMP-mediated signaling that triggers growth hormone synthesis and secretion. The amino acid modifications extend the peptide's biological half-life from under 10 minutes (native GHRH) to approximately 30 minutes, enabling meaningful GH pulse amplification while still preserving physiological pulsatile release patterns. Research on this modified GHRH analogue demonstrates it produces GH elevations within 15-30 minutes of administration, with return to baseline within 2-3 hours, mimicking natural GH pulse kinetics. Studies suggest CJC-1295 without DAC may support skin thickness and collagen production through GH-mediated IGF-1 elevation (Ionescu and Bhatt, Growth Hormone and IGF Research). Compared to the DAC-conjugated version (CJC-1295 with DAC), the non-DAC form produces shorter, more discrete GH pulses rather than sustained 7-10 day GH elevation, which some research protocols prefer for mimicking physiological patterns. It is frequently paired with ghrelin mimetics like ipamorelin for synergistic effect. Store lyophilized powder at -20C; reconstitute with bacteriostatic water and refrigerate at 2-8C for up to 21 days. This peptide is studied by endocrinology research departments, anti-aging medicine laboratories, and body composition research centers investigating GHRH axis modulation.

CJC-1295 (without DAC) Research Applications

In published and preclinical research, CJC-1295 (without DAC) has been studied across the following areas:

  • Pituitary GH release stimulation
  • Skin thickness and collagen activity
  • Muscle hypertrophy studies
  • Cardiac tissue repair research

CJC-1295 (without DAC) in Research: Reconstitution & Study Concentrations

CJC-1295 without DAC (Modified GRF 1-29) is a GHRH analog with four amino-acid substitutions that increase stability relative to native GHRH, but without the albumin-binding Drug Affinity Complex of the DAC variant. This gives it a short half-life studied for pulsatile secretion profiles. Reconstitute the lyophilized peptide with bacteriostatic water for research use.

Worked example: a 10mg vial reconstituted with 2 mL of bacteriostatic water yields 5.00 mg/mL.

Open the reconstitution calculator

How CJC-1295 (without DAC) Compares

Researchers frequently evaluate CJC-1295 (without DAC) alongside related compounds:

CJC-1295 (without DAC) — Frequently Asked Questions

What is CJC-1295 (without DAC) and how does it work?
CJC-1295 without DAC (also called Mod GRF 1-29) is a modified growth hormone-releasing hormone analogue consisting of the first 29 amino acids of GHRH with four amino acid substitutions (positions 2, 8, 15, and 27). These modifications protect it from enzymatic degradation by DPP-IV, extending its half-life to approximately 30 minutes. It stimulates pulsatile GH release by binding to GHRH receptors on pituitary somatotroph cells.
What research has been done on CJC-1295 (without DAC)?
Published research in the Journal of Clinical Endocrinology & Metabolism demonstrated that CJC-1295 produced dose-dependent increases in GH and IGF-1 levels. Studies have shown it amplifies natural GH pulsatility rather than creating a continuous GH elevation, which more closely mimics physiological GH secretion patterns. Additional research has explored its effects on body composition, skin collagen density, and cardiac tissue repair in animal models.
How does CJC-1295 without DAC compare to CJC-1295 with DAC?
The key difference is the Drug Affinity Complex (DAC). Without DAC, CJC-1295 has a half-life of approximately 30 minutes and produces acute GH pulses that mimic natural secretion. With DAC, albumin binding extends the half-life to 6-8 days, creating sustained GH elevation. Researchers studying pulsatile GH patterns prefer the non-DAC version, while sustained GH exposure models use the DAC variant.
What is the recommended reconstitution protocol for CJC-1295 (without DAC)?
For this 10mg vial, add 3 mL of bacteriostatic water to yield a concentration of 3.33mg/mL. Draw 6 units on a 1mL insulin syringe for a 200 mcg dose. Inject BAC water slowly along the inner vial wall — do not shake. Allow the powder to dissolve fully (2–5 minutes). Administer in the PM. Use 5 days on, 2 days off. Refrigerate reconstituted solution at 2–8°C and use within 30 days.
Is CJC-1295 (without DAC) legal to buy for research?
CJC-1295 (without DAC) is sold in the United States as a research chemical for laboratory and in-vitro use only. It is not approved by the FDA for human use and is not sold for human consumption. Researchers are responsible for compliance with all applicable federal, state, and institutional regulations.
How is CJC-1295 (without DAC) reconstituted for research use?
CJC-1295 (without DAC) ships as a lyophilized (freeze-dried) powder and is reconstituted with bacteriostatic or sterile water before use in research. The volume of solvent added determines the working concentration — use the Elyte reconstitution calculator to derive the exact concentration for a given vial size and solvent volume.
Does CJC-1295 (without DAC) come with a Certificate of Analysis?
Yes. Every batch of CJC-1295 (without DAC) from Elyte Peptides ships with a third-party Certificate of Analysis (COA) documenting identity and HPLC purity (≥98%), so research results can be traced to a verified lot.
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