Mitochondrial & Energy Research Guide

ARA-290: Dosage, Benefits & Research Guide

Key Facts

ARA-290 is a mitochondrial & energy research peptide (C45H68N12O15, MW 1009.1 g/mol). Cibinetide (ARA-290) is an 11-amino-acid erythropoietin-derived peptide studied for tissue-protective and anti-inflammatory signaling. For laboratory research use only. It is supplied as a lyophilized powder for laboratory and in-vitro research use only — not for human consumption.

Classification	Cibinetide (ARA-290) is an 11-amino-acid erythropoietin-derived peptide studied for tissue-protective and anti-inflammatory signaling. For laboratory research use only.
Molecular Formula	C45H68N12O15
Molecular Weight	1009.1 g/mol
CAS Number	1208243-50-8
Research Half-Life	Not established in published literature
Form	Lyophilized powder
Research Category	Mitochondrial & Energy

What is ARA-290?

ARA-290, also known as cibinetide, is a small peptide derived from the structure of erythropoietin that selectively engages the innate repair receptor (a heteromer of the EPO receptor and the CD131 beta-common receptor) without stimulating erythropoiesis. Research has explored its role in modulating inflammatory cascades, supporting neuronal and vascular tissue under stress, and influencing pain pathways associated with small-fiber neuropathy. Because it does not raise hematocrit, it has been investigated as a tool for studying tissue-protective EPO signaling in isolation. This compound is supplied as a lyophilized powder for in-vitro and laboratory research use only and is not intended for human or veterinary use.

ARA-290 Research Applications

In published and preclinical research, ARA-290 has been studied across the following areas:

Innate repair receptor signaling research
Anti-inflammatory pathway studies
Neuroprotection and small-fiber neuropathy models
Tissue repair research

ARA-290 in Research: Reconstitution & Study Concentrations

ARA-290 is supplied as a lyophilized powder. For laboratory research it is reconstituted with bacteriostatic or sterile water; the solvent volume sets the working concentration. Published studies select concentrations specific to the assay or model system — there is no human dose, as ARA-290 is not approved for human use. Researchers should reference the primary literature for the model in question and document the exact lot COA.

Worked example: a 10mg vial reconstituted with 2 mL of bacteriostatic water yields 5.00 mg/mL.

Open the reconstitution calculator

ARA-290 — Frequently Asked Questions

What is ARA-290?

Cibinetide (ARA-290) is an 11-amino-acid erythropoietin-derived peptide studied for tissue-protective and anti-inflammatory signaling. For laboratory research use only. It is supplied in 10mg vials and intended strictly for in-vitro and laboratory research use only.

How should ARA-290 be stored?

ARA-290 should be stored at -20°C for long-term storage or 2-8°C for short-term use. Keep the vial sealed and protected from light, moisture, and repeated freeze-thaw cycles. Once reconstituted, store at 2-8°C and use within 30 days.

What purity is ARA-290?

ARA-290 is manufactured to a minimum purity of ≥98% as verified by HPLC analysis, with identity confirmed by mass spectrometry. Each batch ships with a Certificate of Analysis (COA).

What is the recommended reconstitution protocol for ARA-290?

For this 10mg vial, reconstitute with 1mL of bacteriostatic water to yield a concentration of 10.0mg/mL. Inject the water slowly along the inner wall of the vial — do not shake or agitate. Allow the lyophilized powder to dissolve fully (typically 2-5 minutes). Store reconstituted solution at 2-8°C and use within 30 days.

Is ARA-290 legal to buy for research?

ARA-290 is sold in the United States as a research chemical for laboratory and in-vitro use only. It is not approved by the FDA for human use and is not sold for human consumption. Researchers are responsible for compliance with all applicable federal, state, and institutional regulations.

How is ARA-290 reconstituted for research use?

ARA-290 ships as a lyophilized (freeze-dried) powder and is reconstituted with bacteriostatic or sterile water before use in research. The volume of solvent added determines the working concentration — use the Elyte reconstitution calculator to derive the exact concentration for a given vial size and solvent volume.

Does ARA-290 come with a Certificate of Analysis?

Yes. Every batch of ARA-290 from Elyte Peptides ships with a third-party Certificate of Analysis (COA) documenting identity and HPLC purity (≥98%), so research results can be traced to a verified lot.

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