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TB-500 (Thymosin Beta-4) 10mg - Research Peptide
Recovery 10mg

TB-500 (Thymosin Beta-4)

$169.00 In Stock

Synthetic 43-amino acid peptide for tissue repair and anti-inflammatory research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Synthetic 43-amino acid peptide for tissue repair and anti-inflammatory research.

TB-500 is the synthetic version of Thymosin Beta-4, a naturally occurring 43-amino acid peptide present in virtually all human and animal cells. Its primary mechanism of action centers on sequestering G-actin monomers, which promotes actin polymerization and cell migration essential for tissue repair. TB-500 also upregulates expression of laminin-5, a key component of the basement membrane, and activates Akt (protein kinase B) signaling, which research indicates promotes cell survival and inhibits apoptosis. Published studies have demonstrated TB-500's wound healing properties in dermal repair models (Malinda et al., Journal of Investigative Dermatology, 1999) and corneal epithelium regeneration. In equine research, Thymosin Beta-4 has been extensively studied for tendon and ligament repair, with published veterinary trials showing accelerated recovery timelines. The peptide's anti-inflammatory properties appear to operate through suppression of NF-kB and reduction of pro-inflammatory cytokines including IL-1beta and TNF-alpha. Compared to BPC-157, TB-500 has a broader tissue distribution and systemic migration capability, making it a preferred research compound for widespread inflammatory conditions rather than localized injury models. The two peptides target complementary repair mechanisms, which is why they are frequently combined in research protocols. Store lyophilized powder at -20C; reconstitute with bacteriostatic water and refrigerate at 2-8C for up to 28 days. TB-500 is investigated by regenerative medicine centers, veterinary research institutions, and cardiology labs studying post-ischemic tissue recovery.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

  • Angiogenesis and blood vessel formation
  • Wound closure and tissue regeneration
  • Collagen synthesis and scar reduction
  • Anti-inflammatory activity in joints

Specifications

Size
10mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder
Molecular Formula
C212H350N56O78S
Molecular Weight
4963.44 g/mol
CAS Number
77591-33-4

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is TB-500 (Thymosin Beta-4) and how does it work?
TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring 43-amino acid peptide found in high concentrations in wound fluid, blood platelets, and other tissues. It functions by sequestering G-actin monomers to promote cell migration, proliferation, and differentiation. TB-500 has also been observed to upregulate actin polymerization, which is essential for angiogenesis and tissue remodeling in preclinical research models.
What research has been done on TB-500?
Published research in the Annals of the New York Academy of Sciences identified Thymosin Beta-4 as a key regulator of actin dynamics and wound healing. Studies in FASEB Journal demonstrated cardiac repair following ischemic injury in mouse models. Additional research has examined its role in hair follicle stem cell activation, corneal wound healing, and anti-fibrotic activity in liver and kidney injury models.
How does TB-500 compare to BPC-157?
TB-500 and BPC-157 target tissue repair through complementary mechanisms. TB-500 works primarily through actin regulation and cell migration, making it particularly studied for cardiovascular tissue, hair follicle, and dermal repair. BPC-157 acts through the NO system and growth factor modulation, with stronger gastrointestinal and tendon-specific research data. Their distinct pathways explain why researchers frequently study them together.
What is the recommended reconstitution protocol for TB-500?
For this 10mg vial, reconstitute with 2mL of bacteriostatic water to achieve a 5mg/mL solution. TB-500 has a larger molecular weight (4963 Da) and may take 3-5 minutes to fully dissolve. Add water slowly along the vial wall without shaking. Store reconstituted solution at 2-8°C and use within 30 days.
What purity testing is performed on TB-500?
TB-500 undergoes HPLC purity analysis (minimum 98%), mass spectrometry for molecular weight verification against the expected 4963.44 g/mol, amino acid composition analysis, and LAL endotoxin testing. Given its larger size, additional tests for aggregation and degradation products are performed. A detailed Certificate of Analysis (COA) accompanies each batch.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.