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Semax 10mg - Research Peptide
Cognitive 10mg

Semax

$75.00 In Stock

Synthetic ACTH analogue for cognitive enhancement and neuroprotection research.

≥98%
HPLC Purity
COA
Included
USA
Based Supplier

Description

Synthetic ACTH analogue for cognitive enhancement and neuroprotection research.

Semax is a synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10), with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Unlike native ACTH, Semax has been structurally modified to eliminate hormonal activity while retaining and enhancing nootropic and neuroprotective properties. It acts primarily by upregulating brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression, supporting neuronal survival and synaptic plasticity. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been the subject of extensive research. Studies published in Doklady Biological Sciences demonstrated that Semax increased BDNF mRNA expression by up to 1.4-fold in the hippocampus and frontal cortex of rodent models. Research by Ashmarin et al. showed cognitive improvements in attention, memory consolidation, and learning tasks. Clinical investigations in stroke models indicated that Semax administration within 6 hours of ischemic events was associated with improved neurological outcomes and reduced infarct progression. Compared to Selank, another Russian-developed nootropic peptide, Semax is more stimulatory and primarily targets cognitive performance and neuroprotection, while Selank leans toward anxiolytic and immunomodulatory effects. Both share favorable safety profiles in preclinical research, but their mechanisms diverge -- Semax through melanocortin pathways and Selank through tuftsin-based immunomodulation. Lyophilized Semax should be stored at -20°C and protected from light. Reconstitute with bacteriostatic water and store at 2-8°C, using within 3-4 weeks. Semax is actively researched by neuroscientists, cognitive psychologists, and stroke researchers investigating neuroprotective interventions.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 10mg of research-grade material.

Research Applications

  • Stroke recovery and neuroprotection
  • Cognitive enhancement and BDNF stimulation
  • Antidepressant and anxiolytic studies
  • Gene expression in memory centers

Specifications

Size
10mg
Purity
≥98% (HPLC)
Form
Lyophilized Powder
Molecular Formula
C37H51N9O10S
Molecular Weight
813.92 g/mol
CAS Number
80714-61-0

Storage & Handling

  • Long-term storage: -20°C in a sealed, light-protected container
  • Short-term storage: 2-8°C (refrigerated) for up to 30 days
  • Reconstituted: Store at 2-8°C and use within 30 days
  • Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
  • Reconstitution: Use bacteriostatic water or sterile water for injection

Frequently Asked Questions

What is Semax and how does it work?
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4-10) — a fragment of adrenocorticotropic hormone. Unlike full ACTH, Semax does not stimulate cortisol production. Instead, it has been observed in preclinical studies to increase brain-derived neurotrophic factor (BDNF) expression, modulate serotonergic and dopaminergic neurotransmission, and enhance neuronal survival through TrkB receptor signaling pathways.
What research has been done on Semax?
Semax was developed at the Institute of Molecular Genetics (Russian Academy of Sciences) and has been studied extensively in Russia for stroke recovery and cognitive enhancement. Published research in Doklady Biological Sciences demonstrated increased BDNF mRNA expression in the hippocampus and prefrontal cortex. Studies in Neuroscience Letters showed neuroprotective effects in ischemic stroke models, with reduced infarct volume and improved functional recovery.
How does Semax compare to Selank?
Both are synthetic neuropeptides from Russian research programs, but they target different pathways. Semax is ACTH-derived and primarily upregulates BDNF, enhancing neuroplasticity and cognitive function. Selank is tuftsin-derived and acts primarily through GABA modulation and enkephalin stabilization, providing anxiolytic effects. Semax is more commonly studied for cognitive performance, while Selank research focuses on anxiety and immune modulation.
What is the recommended reconstitution protocol for Semax?
For this 10mg vial, reconstitute with 2mL of bacteriostatic water for a 5mg/mL solution. Semax dissolves quickly (1-2 minutes) due to its relatively low molecular weight (813.92 g/mol). For intranasal research applications, sterile saline may be preferred as the diluent. Store reconstituted solution at 2-8°C and use within 30 days.
What purity testing is performed on Semax?
Semax undergoes HPLC purity analysis (minimum 98%), mass spectrometry for molecular weight confirmation (813.92 g/mol), and amino acid analysis to verify the correct ACTH(4-10) sequence. Specific attention is paid to methionine oxidation, which can reduce bioactivity. Endotoxin testing and residual solvent analysis are performed. A Certificate of Analysis (COA) is included with every batch.

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Research Use Only. This product is not intended for human consumption, therapeutic use, or diagnostic purposes. All peptides sold by Elyte Peptides are strictly for in-vitro research and laboratory use. By purchasing, you agree to use this product in compliance with all applicable laws and regulations.