DSIP

Description

Delta sleep-inducing peptide for sleep and cognitive research.

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from rabbit cerebral venous blood during induced sleep by Schoenenberger and Monnier in 1977. DSIP modulates sleep architecture by promoting delta wave (slow-wave) sleep patterns through interactions with multiple neurotransmitter systems, including GABAergic, glutamatergic, and opioidergic pathways. It also influences hypothalamic-pituitary axis regulation, affecting cortisol and growth hormone secretion patterns. Studies published in Peptides demonstrated that DSIP administration normalized disturbed sleep patterns in animal models of chronic stress without producing the sedation or rebound effects associated with classical hypnotic agents. Research by Graf and Kastin (1986) in Neuroscience & Biobehavioral Reviews characterized DSIP's ability to cross the blood-brain barrier and its unusually long biological half-life relative to other neuropeptides. Additional investigations have indicated stress-protective effects, with DSIP reducing corticotropin levels and modulating the hypothalamic stress response. Unlike pharmaceutical sleep aids such as benzodiazepines or Z-drugs, DSIP does not directly suppress CNS activity. Instead, research suggests it normalizes sleep architecture, making it of interest for studying physiological rather than pharmacological sleep regulation. Compared to melatonin, DSIP operates through fundamentally different mechanisms, targeting delta wave promotion rather than circadian rhythm entrainment. Store lyophilized DSIP at -20°C, protected from light and moisture. Reconstitute with bacteriostatic water and refrigerate at 2-8°C, using within 4 weeks. DSIP is studied by sleep researchers, neuroendocrinologists, and stress physiologists investigating non-pharmacological approaches to sleep architecture restoration.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 15mg of research-grade material.

Research Applications

• Sleep regulation studies
• Cognitive focus and neuroprotection
• Stress response modulation
• Circadian rhythm research

Specifications

Size

15mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection