NAD+

Description

Essential coenzyme for energy production and DNA repair research.

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in every living cell, serving as a critical electron carrier in metabolic redox reactions including glycolysis, the citric acid cycle, and oxidative phosphorylation. Beyond energy metabolism, NAD+ functions as a substrate for sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs) involved in DNA repair, and CD38/CD157 ectoenzymes involved in calcium signaling. NAD+ levels decline significantly with age, and this decline has been implicated as a driver of metabolic dysfunction and cellular senescence. Seminal research by Imai and Guarente (2014) in Trends in Cell Biology established the NAD+ depletion theory of aging, demonstrating that declining NAD+ levels impair sirtuin activity and mitochondrial function. Studies by Yoshino et al. (2011) in Cell Metabolism showed that NAD+ precursor supplementation restored metabolic function in aged and diet-induced obese mice. Research in Science by Li et al. demonstrated that NAD+ repletion improved muscle stem cell function and extended lifespan in aged murine models through SIRT1-dependent mechanisms. This 500mg formulation provides a direct NAD+ supply for research applications. Compared to precursors like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside), which require enzymatic conversion, direct NAD+ bypasses biosynthetic pathway bottlenecks, though its larger molecular size presents different cellular uptake considerations. Each approach offers distinct advantages depending on the research model. Store lyophilized NAD+ at -20°C, protected from light and moisture, as it is hygroscopic. Reconstitute with bacteriostatic water and store at 2-8°C, using within 2-3 weeks, as NAD+ is susceptible to hydrolytic degradation in solution. NAD+ is studied by aging researchers, metabolic scientists, DNA repair biologists, and mitochondrial function specialists.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 500mg of research-grade material.

Research Applications

• Aging and metabolic health studies
• Neurodegenerative disease research
• DNA repair and ischemic stress
• Liver, kidney, and cardiac function

Specifications

Size

500mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Molecular Formula

C21H27N7O14P2

Molecular Weight

663.43 g/mol

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection