IGF-1 LR3

Description

Extended-activity IGF-1 analogue for cell proliferation and tissue repair research.

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified 83-amino acid analogue of human IGF-1 in which glutamic acid at position 3 is replaced with arginine, and a 13-amino acid N-terminal extension peptide is added. These modifications significantly reduce binding to IGF-binding proteins (IGFBPs), resulting in a much higher proportion of free, bioactive peptide in circulation compared to native IGF-1. The mechanism of action involves binding to the IGF-1 receptor (IGF-1R), a tyrosine kinase receptor that activates the PI3K/Akt and MAPK/ERK signaling cascades to promote cell proliferation, differentiation, and survival. Research demonstrates that IGF-1 LR3 has approximately 2-3 times the potency of native IGF-1 in cell culture proliferation assays due to its reduced IGFBP sequestration (Francis et al., Journal of Molecular Endocrinology, 1992). In muscle biology research, IGF-1 signaling promotes satellite cell activation and myofiber hypertrophy while simultaneously inhibiting myostatin-mediated atrophy pathways. Studies also indicate IGF-1 LR3 promotes both hyperplasia (new cell formation) and hypertrophy (cell enlargement), distinguishing it from GH secretagogues that primarily drive hypertrophy. Compared to native IGF-1, LR3 has a significantly extended half-life of approximately 20-30 hours versus 12-15 minutes, making it substantially more practical for research applications. Store lyophilized powder at -20C; reconstitute with 0.1M acetic acid or bacteriostatic water and refrigerate at 2-8C, using reconstituted material within 30 days. IGF-1 LR3 is studied by cell biology laboratories, muscle physiology researchers, cancer biology departments investigating IGF-1R signaling, and metabolic research institutions.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 1mg of research-grade material.

Research Applications

• Cell proliferation and hyperplasia studies
• Metabolic function and diabetes research
• Muscle preservation and myostatin inhibition
• Longevity and anti-aging research

Specifications

Size

1mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Molecular Weight

9117.5 g/mol

CAS Number

946870-92-4

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection