SLU-PP-322

Description

Synthetic research peptide for neuromodulatory and metabolic studies.

SLU-PP-332 is a synthetic small-molecule agonist of estrogen-related receptors (ERRs), specifically ERR-alpha, ERR-beta, and ERR-gamma. These orphan nuclear receptors regulate the transcription of genes involved in mitochondrial biogenesis, oxidative phosphorylation, and fatty acid metabolism. Research from the Bhatt laboratory at Saint Louis University (published in ACS Chemical Biology, 2023) demonstrated that SLU-PP-332 administration in mouse models increased exercise endurance and fatigue resistance without physical training, earning it attention as a potential exercise mimetic compound. The mechanism involves upregulating PGC-1alpha-dependent gene networks that enhance mitochondrial density and oxidative capacity in skeletal muscle. In ischemic stroke models, ERR activation by SLU-PP-332 has shown neuroprotective effects by preserving mitochondrial membrane integrity and reducing reactive oxygen species production (Willy et al., published in Cell Chemical Biology). Compared to other exercise mimetics such as AICAR (AMPK activator) or GW501516 (PPAR-delta agonist), SLU-PP-332 targets a distinct upstream transcriptional pathway that coordinately activates multiple metabolic gene programs rather than a single signaling cascade. Research also suggests potential applications in chronic fatigue and neurodegenerative conditions where mitochondrial dysfunction is implicated. Store lyophilized powder at -20C in a desiccated environment; reconstitute in DMSO or appropriate vehicle per protocol specifications. SLU-PP-332 is investigated by exercise physiology researchers, neuroscience departments studying metabolic neuroprotection, and pharmacology labs exploring nuclear receptor biology.

This product is supplied as a lyophilized powder and is intended for laboratory and research use only. Not for human consumption. Each vial contains 5mg of research-grade material.

Research Applications

• Neuroprotection and ischemic stroke models
• Cognitive enhancement research
• Mitochondrial and chronic fatigue therapies
• Weight management pathways

Specifications

Size

5mg

Purity

≥98% (HPLC)

Form

Lyophilized Powder

Storage & Handling

• Long-term storage: -20°C in a sealed, light-protected container
• Short-term storage: 2-8°C (refrigerated) for up to 30 days
• Reconstituted: Store at 2-8°C and use within 30 days
• Avoid: Repeated freeze-thaw cycles, direct sunlight, and moisture exposure
• Reconstitution: Use bacteriostatic water or sterile water for injection